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KMID : 0191120130280010062
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Journal of Korean Medical Science
2013 Volume.28 No. 1 p.62 ~ p.66
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Antimicrobial Susceptibility of Stenotrophomonas maltophilia Isolates from Korea, and the Activity of Antimicrobial Combinations against the Isolates
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Chung Hae-Sun
Hong Seong-Geun
Kim Young-Ree
Shin Kyeong-Seob
Whang Dong-Hee
Ahn Jee-Young
Park Yeon-Joon
Uh Young
Chulhun L. Chang
Shin Jong-Hee
Lee Hye-Soo
Lee Kyung-Won
Chong Yun-Sop
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Abstract
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The aim of this study was to determine antimicrobial susceptibility of recent clinical Stenotrophomonas maltophilia isolates from Korea, and to compare the activity levels of several combinations of antimicrobials. A total of 206 non-duplicate clinical isolates of S. maltophilia was collected in 2010 from 11 university hospitals. Antimicrobial susceptibility testing was performed using the Clinical Laboratory Standards Institute agar dilution method. In vitro activity of antimicrobial combinations was tested using the checkerboard method. The susceptibility rates to trimethoprim-sulfamethoxazole and minocycline were 96% and 99%, respectively. The susceptibility rate to levofloxacin was 64%. All of four antimicrobial combinations showed synergy against many S. maltophilia isolates. A combination of trimethoprim-sulfamethoxazole plus ticarcillin-clavulanate was most synergistic among the combinations. None of the combinations showed antagonistic activity. Therefore, some of the combinations may be more useful than individual drugs in the treatment of S. maltophilia infection. Further clinical studies are warranted to validate our in vitro test results.
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KEYWORD
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Stenotrophomonas maltophilia, Combination Drug Therapy, Trimethoprim-Sulfamethoxazole, Ticarcillin-Clavulanate
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